Can accuracy be affected by time on the wrist between full winding?

[burnthesehills]

Let’s say for example I wear a Sub for several weeks or even months on end without winding it. Granted it is being automatically wound while worn by the rotor. But depending on activity level and time on the wrist (versus in a drawer) I assume the mainspring will eventually wind down to some degree. Could this affect accuracy in terms of the watch losing more time? Conversely, would letting the watch completely wind down and giving it a full wind with a fresh start so to speak be better for accuracy?

Or is there basically no relation?